From time to time, I am invited to review papers that are fundamentally flawed. Those papers are written so poorly that I can decide their fates in 1 minute. To save myself from typing again, below is a template. I will just copy and paste.
This paper is very poorly written.
1. Lack of background from the biology problem to the computing counterpart to help broader audiences understand the problem.
2. Equations without explanation of the variables used.
3. No clear distinction between previous work and the authors' contribution(s).
4. Typesetting making reading extremely difficult, e.g., lengthy English phrases in math/italic fonts.
5. Too many English problems.
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